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KMID : 1035620190070020086
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Allergy Asthma & Respiratory Disease
2019 Volume.7 No. 2 p.86 ~ p.91
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Comparison of clinical severity between single- and coinfections of respiratory syncytial virus and influenza virus with common respiratory viruses
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Park Jin-Sung
Chu Shou-Yu
Shin Yi-Yeon
Ryu In-Kyung
Tang Chih-Lung
Choi Jun-Gi
Kim Hyo-Bin
Kim Chang-Keun
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Abstract
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Purpose: Multiple virus infections may affect clinical severity. We investigated the effect of coinfection of respiratory syncytial virus (RSV) and influenza virus with other respiratory viruses on clinical severity.
Methods: Data from 634 samples of a single tertiary hospital between September 2014 and April 2015 were analyzed for clinical characteristics (fever duration and O2 need, steroid use, and ICU care) between single infection and coinfection of RSV (n=290) and influenza virus (n=74) with 16 common respiratory viruses from hospitalized children.
Results: The RSV coinfection group (n=109) (3.1±2.7 days) showed significantly longer fever duration than the RSV single infection group (n=181) (2.6±2.6 days) (P=0.04), while there was no difference in O2 need, steroid use or ICU care in the 2 groups. The influenza coinfection group (n=38) showed significantly higher O2 need than the influenza single infection group (n=36) (21.1% vs. 5.6%, P=0.05), while there was no difference in fever duration between the 2 groups.
Conclusion: The results indicate that RSV and Influenza coinfections can increase clinical severity and that the severity may be influenced by the nature of coinfecting viruses.
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KEYWORD
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Respiratory syncytial viruses, Influenza, Fever, Dyspnea, Coinfection
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